Chao-ting Wu

The paper introduces tkPAINT, a method combining TIRF microscopy and Tokuyasu cryosectioning to enhance DNA-PAINT for single-protein imaging and molecular counting with 3 nm precision across cells and tissues.

This paper introduces Decode-PAINT, a method for high-resolution chromatin imaging, and demonstrates its application to study X chromosome structure in cells.

The paper investigates the 3D organization of Drosophila melanogaster pericentromeric heterochromatin domains and their spatial interactions with euchromatic regions enriched in H3K9me2/3 marks.

A haplotype-resolved Hi-C approach reveals structured homolog pairing in early Drosophila embryos, correlated with Zelda-mediated chromatin accessibility.

The paper uses haplotype-resolved Hi-C to reveal structured homolog pairing and its global impact on gene activity in hybrid Drosophila cells.

The paper identifies the sequence composition of Drosophila melanogaster centromeres, showing they are composed of retroelement islands flanked by satellite repeats, with G2/Jockey-3 being the most enriched retroelement.

The paper uses super-resolution imaging and integrative modeling to achieve 10 kb resolution of chromosome folding.

This study examines the relationship between ultraconserved elements and three-dimensional genome organization in human and mouse genomes, finding UCEs enriched in contact domains and linked to specific biological processes.

OligoMiner designs genome-scale oligo FISH probes with customizable parameters and evaluates probe specificity using supervised learning, demonstrating scalability across model organisms.

The paper identifies a link between structural genomic disruptions near ultraconserved elements and neurodevelopmental phenotypes.