Cancer BiologyCell Death and DifferentiationPeer-reviewed
Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition
Tamara Isermann, Kim Lucia Schneider, Florian Wegwitz…·Ramona Schulz‐Heddergott
This study shows that combining HSP90 inhibitors with p53 activation or CDK4/6 inhibition enhances colorectal cancer therapy by disrupting the HSF1-HSR feedback loop.