Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition
Tamara Isermann, Kim Lucia Schneider, Florian Wegwitz, Tiago De Oliveira, Lena‐Christin Conradi, Valery Volk, Friedrich Feuerhake, Bjoern Papke, Sebastian Stintzing, Bettina Mundt, Florian Kühnel, Ute Martha Moll, Ramona Schulz‐Heddergott
This study shows that combining HSP90 inhibitors with p53 activation or CDK4/6 inhibition enhances colorectal cancer therapy by disrupting the HSF1-HSR feedback loop.
Cell Death and Differentiation · Apr 9, 2025Peer-reviewedCancer Biology