This study shows that inhibiting MLCK blocks axon regeneration in mice, while inhibiting MLCP promotes regrowth in both peripheral and central nervous systems.

bioRxiv · Jul 30, 2024 · PreprintNeuroscience

The manipulation of spinal motor neuron axonal growth promotes spinal cord repair

Feng Wang, Xin‐Ya Fu, Meimei Li, Xingran Wang, Jile Xie, Jinjin Ma, Yan‐Xia Ma, Saijilafu

This study shows that knocking out pten in mature spinal motor neurons enhances axonal regeneration and synaptic reconnection after spinal cord injury.

bioRxiv · Nov 13, 2021 · PreprintNeuroscience

Inhibition of Pten activity promotes IB4 positive sensory neuronal axon growth

Li-Yu Zhou, Feng Han, Shi‐Bin Qi, Jinjin Ma, Yan‐Xia Ma, Hong-Cheng Zhang, Jile Xie, Xin‐Ya Fu, Jianquan Chen, Bin Li, Huilin Yang, Feng Zhou, Saijilafu

This study shows that inhibiting PTEN promotes axon regeneration in adult sensory neurons, particularly in IB4-positive neurons following peripheral axotomy.

Journal of Cellular and Molecular Medicine · Aug 3, 2020Peer-reviewedNeuroscience

Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone

Feng Xi, Renjie Xu, Jinhui Xu, Jinjin Ma, Wei‐Hua Wang, Feng Wang, Yan‐Xia Ma, Shi‐Bin Qi, Hong‐Cheng Zhang, Hao‐Nan Zhang, Xu‐Zhen Qin, Jianquan Chen, Bin Li, Chang‐Mei Liu, Huilin Yang, , Saijilafu

This study shows that CaMKII regulates axon growth by modulating F-actin length in growth cones, with implications for axon regeneration in both peripheral and central nervous systems.

Journal of Cellular Physiology · May 27, 2019Peer-reviewedNeuroscience