Saijilafu

This study investigates the roles of Kdm6a and Kdm6b in neural regeneration, finding they regulate axon regeneration and RGC survival with distinct mechanisms and identifying Klf4 as a downstream target.

This study shows that inhibiting MLCK blocks axon regeneration in mice, while inhibiting MLCP promotes regrowth in both peripheral and central nervous systems.

This study shows that knocking out pten in mature spinal motor neurons enhances axonal regeneration and synaptic reconnection after spinal cord injury.

This study shows that inhibiting PTEN promotes axon regeneration in adult sensory neurons, particularly in IB4-positive neurons following peripheral axotomy.

This study shows that knocking out myosin IIA/B in retinal ganglion cells promotes optic nerve regeneration, with synergistic effects when combined with Lin28 overexpression.

The paper identifies TERT and p53 as regulators of axon regeneration downstream of c-Myc in the CNS and PNS, showing p53 overexpression promotes regeneration.

This study shows that CaMKII regulates axon growth by modulating F-actin length in growth cones, with implications for axon regeneration in both peripheral and central nervous systems.