Atypical T cell receptor signalling permits distinct gut gd T cell responses to healthy versus dysregulated tissues
Leticia Monin, Florencia Cano, James Axford, Grace Cooper, Gerard Hernández-Mir, Klaus Okkenhaug, Adrian Hayday
The paper identifies an atypical TCR signaling pathway in gut γδ T cells that limits activation in healthy tissues but allows full responses during tissue perturbation.
bioRxiv · Oct 16, 2026 · PreprintImmunology