Klaus Okkenhaug

This paper identifies a redox-gated phagocytic rheostat in neutrophils by analyzing phosphoproteomic and functional responses to bacterial exposure.

The paper identifies an atypical TCR signaling pathway in gut γδ T cells that limits activation in healthy tissues but allows full responses during tissue perturbation.

The paper identifies Posaconazole as a CYP11A1 inhibitor that enhances anti-tumour immunity in a mouse model of lung metastasis.

The paper identifies hexa-acylated lipopolysaccharides from the gut microbiome as a biomarker and enhancer of anti-PD-1 immunotherapy responses in melanoma patients.

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.

This study investigates neurodevelopmental deficits in activated PI3Kδ syndrome (APDS) using patient assessments and a murine model, showing visuomotor and motor impairments linked to PIK3CD mutations.

The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.