C. Mclean

BioNAR is a Bioconductor package for analyzing biological networks to quantify and rank vertices based on topology and clustering, enabling discovery of disease and function-enriched subcomplexes.

The paper constructs a configurable synaptic proteome network model to analyze molecular mechanisms of disease co-morbidity by integrating proteomic and interaction data.

The paper identifies regional differences in the postsynaptic proteome across mouse brain regions using proteomic mass spectrometry, revealing unique compositional signatures correlated with anatomy and embryology.