Seth G. N. Grant

This study shows that traumatic brain injury in mice disrupts and remodels excitatory synapse populations across multiple brain regions, similar to other plasticity-inducing conditions.

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

The paper discovers a new synaptic structure called the Honeycomb Synapse in the spinal cord, showing its vulnerability in ALS models.

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

The paper examines region- and layer-specific glutamatergic synapse maturation in the developing cortex, finding that layers involved in higher-order circuits mature later, particularly in layer 1 during adolescence.

The paper introduces PRMix, an augmentation method for improving segmentation of mouse brain regions, and presents a benchmark dataset for anatomical delineation.

The paper develops computational models to explain synaptic protein distribution patterns in neurons by integrating molecular transport and local synaptic demand mechanisms across different ages and cell types.

The paper introduces NanoSYNMAP to map synaptic nanoarchitecture across the mouse lifespan, revealing how molecular proximity shapes synapse diversity.

The paper measures synaptic protein distributions in mouse brains to identify architectural patterns and their developmental changes.

The paper introduces overlap area (OA) as a new effect size measure for neuroscience research, showing it detects environmental enrichment effects on the mouse brain synaptome.

The paper shows that environmental enrichment and visual deprivation cause large-scale, synapse-type-specific reorganization across the brain, revealing a conserved mechanism of synaptome plasticity.

This study investigates the developmental plasticity of cochlear inner hair cell ribbon synapses using live-cell imaging, revealing activity-dependent mechanisms in their structural maturation.

The paper examines SV2A expression in synapses across mouse and human brains, revealing regional and synaptic variability that challenges current PET imaging interpretations.

SynaptopathyDB integrates synapse proteomic and genetic data to identify synaptic gene variants associated with neurological and systemic disorders.

The paper shows that synapse diversity in the mouse brain influences regional dynamics, with specific synapse types linked to distinct patterns of brain activity and connectivity.

This study identifies a synaptic-astrocytic proteomic signature associated with synapse loss in Alzheimer's Disease across different disease stages.

This study demonstrates MINFLUX fluorescence nanoscopy's ability to achieve sub-10 nm resolution for protein localization in thick mouse brain tissue sections.

This study uses 3D super-resolution microscopy to analyze PSD95 nanoarchitecture in the mouse brain, revealing diffuse supercomplexes outside synapses and distinct subtypes within synapses.

The paper investigates the sequential replacement of PSD95 subunits in synaptic supercomplexes, finding that this process is slowest in the cortex where PSD95 has the longest lifetime.

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

This study uses super-resolution microscopy to characterize phosphorylated TDP-43 expression in spinal cord synapses of ALS mice and healthy controls.

This paper introduces a method for saturated reconstruction of living brain tissue using advanced imaging and deep learning to achieve high-resolution, volumetric analysis of neural structures over time.

The paper quantifies PSD95 protein lifetime in mouse synapses across lifespan and brain regions, revealing distinct patterns linked to development, behavior, and aging.

This study calculates pathway-based polygenic risk scores for schizophrenia using gene-sets related to synaptic function and histone modification, and finds associations with neuroimaging and clinical traits in UK Biobank.

The paper investigates tripartite synapse loss in ALS models and human tissue, finding selective vulnerability of these synapses in both mice and humans.

The paper shows that synaptome remodelling in mice with Pax6 mutation restores normal developmental trajectory, reversing neurodevelopmental disorder symptoms.

This study uses cryo-electron tomography to reveal the 3D molecular architecture of glutamatergic synapses in the adult mammalian forebrain, showing a synaptoplasm rather than a distinct PSD.

The paper constructs a configurable synaptic proteome network model to analyze molecular mechanisms of disease co-morbidity by integrating proteomic and interaction data.