Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas.
Neharika Jain, Emmanuel C. Ogbonna, Zoltan Maliga, Connor A. Jacobson, Liang Zhang, Angela R. Shih, Jacob M. Rosenberg, Haroon Kalam, Andréanne Gagné, Isaac H. Solomon, Sandro Santagata, Peter Karl Sorger, Bree B. Aldridge, Amanda Jezek Martinot
This study identifies suppressive myeloid cell populations in human TB granulomas using spatial transcriptomics and single-cell immunophenotyping, revealing IDO1+ dendritic cells as key regulators of immune suppression.
bioRxiv · Mar 10, 2025 · PreprintPathology