Multiomic characterization, early detection, and therapeutic targeting of myeloid sarcoma
Bettina Nadorp, Audrey Lasry, Sanam Loghavi, Ravi Patel, Hager M. Mansour, Benjamin Kelly, Christopher J. Walker, Jill L. Buss, Isaiah Boateng, Wafa Al-Santli, Zoe B. Ciantra, Rebecca J. Austin, Adrienne Heyrosa, Helee Desai, Andrea Laganson, , Ann‐Kathrin Eisfeld
This study characterizes myeloid sarcoma through multi-omic profiling, identifies RAS pathway activation as a hallmark, and shows RAS inhibition reduces tumor burden in mouse models.
bioRxiv · Dec 5, 2025 · PreprintCancer Biology