Ashraf N. Abdo

Cyclic Peptides Target CAPON and Modulate Cellular Responses under Alzheimers Disease-Relevant Stress

This study identifies cyclic peptide ligands targeting CAPON, showing reduced neuronal toxicity and tau phosphorylation under Alzheimer's disease stress conditions.

Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces

This paper introduces AtlasNMR, a framework using NMR ensembles to identify small molecules targeting dynamic protein-protein interfaces, demonstrating its effectiveness with the nNOS PDZ domain.

Discovery of MA48, a Small Molecule Inhibitor of CAPON (NOS1AP)-NOS1 Protein-Protein Interaction

The paper identifies MA48 as a small molecule inhibitor of CAPON-nNOS interaction through screening and validation, suggesting its potential as a therapeutic target for neurodegenerative diseases.

Identification of a First-In-Class Small Molecule CAPON Binder Using Affinity Selection-Mass Spectrometry Screening

This study identifies the first small-molecule binder of CAPON using AS-MS screening and validates its binding affinity.

Hair test reveals plasticity of human chronotype

HairTime estimates chronotype from a single hair sample, showing it is influenced by age, sex, and work schedules, with lower circadian amplitude reducing prediction accuracy.