Sungwoo Cho

This paper identifies and optimizes a molecular glue that stabilizes the NOS1AP-SCRIB interaction, showing therapeutic effects in Alzheimer's patient-derived neurons.

CAPTOR-1, a small molecule inhibitor of NOS1AP-tau interaction, reduces tau pathology and improves cognition in AD models.

A CD28-selective small molecule blocks pathogenic T cell activation and preserves Treg function unlike Abatacept in IBD models.

This paper introduces AtlasNMR, a framework using NMR ensembles to identify small molecules targeting dynamic protein-protein interfaces, demonstrating its effectiveness with the nNOS PDZ domain.

This paper identifies S9, a small molecule TREM2 agonist that reprograms microglia and protects synapses in Alzheimer's models, showing therapeutic potential.

This study identifies a binding site for the TREM2 agonist VG-3927 within the ectodomain hydrophobic groove and shows that Aβ1-42 competes with VG-3927 for binding.

This study identifies a new small molecule scaffold that modulates TREM2 signaling through fragment-based drug discovery and SAR analysis.

The paper identifies MA48 as a small molecule inhibitor of CAPON-nNOS interaction through screening and validation, suggesting its potential as a therapeutic target for neurodegenerative diseases.

The paper develops a NanoBiT-based assay for high-throughput screening of NOS1-CAPON interaction inhibitors, identifying 19 compounds with IC50 values below 30 M.

This paper identifies a small molecule TREM2 modulator, EN020, that enhances microglial phagocytosis better than a known agonist.

The paper designs cyclic peptides targeting TREM2 using AI tools and validates their binding and stability.

As48 is a small molecule that activates TREM2 and inhibits its shedding, offering a dual mechanism to enhance microglial function in Alzheimer's disease.