This study examines changes in brain connectivity in PTSD patients after treatment, finding reduced salience network connectivity with PCT and increased central executive network connectivity with CPT.

Chronic Stress · Jan 1, 2019Peer-reviewedNeuroscience

Rapamycin, an Immunosuppressant and mTORC1 Inhibitor, Triples the antidepressant Response Rate of Ketamine at 2 Weeks Following Treatment: A double-blind, placebo-controlled, cross-over, randomized clinical trial

Chadi G. Abdallah, Lynnette A. Averill, Ralitza V. Gueorguieva, Selin Goktas, Prerana Purohit, Mohini Ranganathan, Deepak Cyril D’Souza, Richard N. Formica, Steven Mark Southwick, Ronald S. Duman, Gerard Sanacora, John Harrison Krystal

This study shows that pretreatment with rapamycin increases the antidepressant response rate of ketamine at 2 weeks but does not affect its acute effects.

bioRxiv · Dec 19, 2018 · PreprintNeuroscience

Salience Network Disruption in US Army Soldiers with PTSD

Chadi G. Abdallah, Christopher L. Averill, Amy E. Ramage, Lynnette A. Averill, Selin Goktas, John Harrison Krystal, John D. Roache, Patricia A. Resick, Stacey Young‐McCaughan, Alan L. Peterson, Peter T. Fox

This study identifies increased salience network connectivity in PTSD using a graph-based topological measure of nodal strength in US Army soldiers.

bioRxiv · Dec 13, 2018 · PreprintNeuroscience