Ronald S. Duman

This study shows that depletion of PFC GFAP+ astroglia induces anhedonia-like behavior, while their activation reverses stress-induced anhedonia, highlighting their role in depression.

This study shows that the sex of human experimenters affects mouse behaviors, stress responses, and drug responses like ketamine, mediated by CRF neurons.

This study identifies transcriptomic changes and genetic factors associated with PTSD using postmortem brain tissue and GWAS data, revealing sex differences and divergence from MDD.

This study shows that a Shank3 mutation causes elevated calcium in dendritic spines due to reduced inhibition from SST interneurons, and correcting this improves learning deficits.

This study shows that ketamine suppresses SST interneurons, leading to increased calcium signals in dendritic spines of pyramidal neurons in the medial prefrontal cortex of awake mice.

This study identifies genetic loci associated with PTSD and its symptoms using a large veteran cohort, showing high genetic correlations between symptom sub-domains and potential drug targets.

This study shows that pretreatment with rapamycin increases the antidepressant response rate of ketamine at 2 weeks but does not affect its acute effects.