The Norepinephrine Metabolite DOPEGAL Confers Locus Coeruleus Tau Vulnerability and Propagation via Asparagine Endopeptidase
Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P. Manfredsson, Xifei Yang, Hongbo Robert Luo, Larry Cameron Liles, David Weinshenker, Keqiang Ye
The paper identifies DOPEGAL as a factor that promotes Tau pathology and propagation in locus coeruleus neurons via AEP cleavage of Tau.
bioRxiv · Jul 2, 2019 · PreprintNeuroscience