Miguel Marchena

The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.

ApTOLL, an aptamer targeting TLR4, shows immunomodulatory and remyelinating effects in MS models and cell cultures.

This study shows that Shh/Smo activation maintains oligodendrocyte precursor cells (OPCs) in an undifferentiated state but is not required for myelination or remyelination.

This study shows that overexpression of anosmin-1 increases dopaminergic neurons and alters striatum organization but does not affect susceptibility to MPTP-induced Parkinsonism.

This study shows that proinsulin activation of the insulin receptor preserves synapses and vision in retinitis pigmentosa by restoring signaling and synaptic connectivity.