TIME-CoExpress: Temporal Trajectory Modeling of Dynamic Gene Co-expression Patterns Using Single-Cell Transcriptomics Data
Shuyi Yang, Anderson Bussing, Giampiero Marra, Michelle Lynn Brinkmeier, Sally Ann Camper, Shannon William Davis, Yen‐Yi Ho
The paper introduces a copula-based method to model non-linear gene co-expression changes along temporal trajectories in scRNA-seq data, applied to study pituitary development in mice.
BMC Bioinformatics · Jul 29, 2025Peer-reviewedGenetics