Michelle Lynn Brinkmeier

PRC2 complex subunit JARID2 regulates embryonic pituitary stem cell differentiation to the POMC lineage

The paper shows that JARID2 promotes pituitary stem cell differentiation to the POMC lineage by regulating chromatin landscapes and gene expression.

TIME-CoExpress: Temporal Trajectory Modeling of Dynamic Gene Co-expression Patterns Using Single-Cell Transcriptomics Data

The paper introduces a copula-based method to model non-linear gene co-expression changes along temporal trajectories in scRNA-seq data, applied to study pituitary development in mice.

Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium

The paper identifies a hypomorphic MYRF variant causing partial loss of function in the RPE, with two novel splicing variants linked to isolated nanophthalmos.

Myelin regulatory factor (Myrf) is a critical early regulator of retinal pigment epithelial development.

This study identifies Myrf as a critical regulator of RPE development, showing its role in melanogenesis, cell survival, and structure through gene regulation and signaling pathways.

Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation

This study shows that Nxn deficiency causes pituitary dysmorphology and reduced Wnt signaling in mice, suggesting potential endocrinological evaluations for Robinow syndrome patients.