W. Frank Lenoir

Discovery of novel putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in AML cells

The paper identifies novel tumor suppressors from CRISPR screens and reveals rewired lipid metabolism in AML cells through functional analysis of gene modules.

Hierarchical organization of the human cell from a cancer coessentiality network

The paper constructs a coessentiality network from CRISPR knockout screens to infer gene function and reveal hierarchical cell organization.

Identifying chemogenetic interactions from CRISPR knockout screens with drugZ

drugZ identifies chemogenetic interactions from CRISPR screens, finding more homologous recombination repair pathway genes and confirming KEAP1 loss as a resistance factor for ERK inhibitors.

The E. coli molecular phenotype under different growth conditions

This study presents a comprehensive transcriptomics and proteomics dataset of E. coli under 34 growth conditions, revealing differences between exponential and stationary phases and differential gene expression under specific stresses.