Chromatin Accessibility Plays a Key Role in Selective Targeting of Hox Proteins
Damiano Porcelli, Bettina Fischer, Steven R. H. Russell, Robert A. White
This study shows that chromatin accessibility determines Hox protein binding selectivity in vivo, independent of cofactors, and proposes a model where affinity-based competition with nucleosomes drives target selection.
Genome biology · Jun 3, 2019Peer-reviewedGenomics