Andrea Maria Isidori

This study shows that Pde5a deficiency prevents diet-induced obesity by enhancing adipose cAMP-PKA activation, leading to fat browning and improved metabolic outcomes.

The paper shows that the L412F polymorphism in TLR3 is associated with severe COVID-19 in males by inhibiting autophagy and reducing TNF production.

The paper identifies a genetic variant in the SELP gene associated with increased thrombosis risk in male COVID-19 patients, suggesting potential for anti-P-selectin antibody therapy.

The paper identifies shorter androgen receptor polyQ alleles as protective against severe COVID-19 in males using machine learning on whole-exome sequencing data from the GEN-COVID cohort.