Single-Cell RNA-Seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during Spermiogenesis
Huanhuan Tan, Weixu Wang, Congjin Zhou, Yanfeng Wang, Shu Zhang, Pinglan Yang, Rui Hong Guo, Wei Chen, Jinwen Zhang, Lan Ye, Yiqiang Cui, Ting Ni, Ke Zheng
This study uses scRNA-seq to show that DDX43 is essential for chromatin remodeling during spermiogenesis, with its deficiency causing defects in sperm nucleus condensation.
Nature Communications · Apr 29, 2023Peer-reviewedDevelopmental Biology