Ting Ni

This study characterizes age-related immune dynamics through multi-layer transcriptomic analysis, revealing non-linear transcriptional reprogramming and novel regulatory elements associated with immune aging.

BioGAIP automates complex bioinformatics tasks using an LLM-powered multi-agent system, making advanced analysis accessible to non-experts through natural language input and graphical interfaces.

This study identifies 413 APA-linked cancer susceptibility genes by integrating GWAS data with APA quantification, showing genetic variants associated with APA explain a large portion of cancer heritability.

This study uses scRNA-seq to show that DDX43 is essential for chromatin remodeling during spermiogenesis, with its deficiency causing defects in sperm nucleus condensation.

This study develops scPolyA-seq to analyze alternative polyadenylation at single cell resolution, finding that many genes use only one polyA site per cell and identifying cell cycle-related polyA site usage switches.

ENIGMA deconvolutes bulk RNA-seq into single-cell-type resolution using matrix completion, validated on simulated and disease-related datasets.

This study shows that alternative polyadenylation (APA) leads to longer 3' UTRs in senescent cells, affecting gene regulation through miRNA and RBP binding sites.

The paper investigates APA regulation in cellular senescence, finding genes in senescent cells preferentially use distal polyadenylation sites, associated with longer 3′ UTRs and senescence-related pathways.