Shu Zhang

Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras

This paper develops PMO-based RNA-degrading chimeras that target SNCA mRNA to reduce α-synuclein levels and prevent pathological aggregation in vitro and in vivo.

Multifunctional nanozyme therapy accelerates hematoma clearance and attenuates genome damage and senescence after intracerebral hemorrhage

This study evaluates a multifunctional nanozyme therapy for intracerebral hemorrhage, showing it accelerates hematoma clearance and reduces genome damage and senescence.

Learning a Continuous Progression Trajectory of Amyloid in Alzheimer's disease

This study introduces SLOPE, a method to model amyloid progression in Alzheimer's disease on a continuous trajectory, showing improved sensitivity to early changes compared to global measures.

Copper-Containing ROS-Scavenging Nanozyme Paradoxically Drives Alpha-Synucleinopathy by Amplifying Nitrosative Stress

The paper shows a copper-containing nanozyme worsens alpha-synucleinopathy by increasing nitrosative stress, while a copper-free version reduces pathology in neurodegenerative models.

α-Synuclein Strain Dynamics Predict Cognitive Transitions in Parkinson's Disease

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

This study uses snRNA-seq in pigs to reveal CLAs promote fat infiltration by altering myofiber types and adipocyte differentiation through JNK pathway inhibition.

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

This study identifies Lag3 as a neuronal receptor for Tau preformed fibrils, essential for their uptake, propagation, and transmission in Tauopathies.

Single-Cell RNA-Seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during Spermiogenesis

This study uses scRNA-seq to show that DDX43 is essential for chromatin remodeling during spermiogenesis, with its deficiency causing defects in sperm nucleus condensation.

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.