NeuroscienceAdvanced SciencePeer-reviewed
Metabolic bypass rescues aberrant S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer's disease human neurons
Alexander Y. Andreyev, Hongmei Yang, Paschalis‐Thomas Doulias…·Stuart A. Lipton
This study identifies a metabolic block in the TCA cycle in Alzheimer's disease neurons and shows that dimethyl succinate treatment rescues mitochondrial function and synapse loss.
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