Author

Nima Dolatabadi

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1

Frequent Co-Authors

Stuart A. LiptoniD· 4 shared Christine BaaliD· 2 shared Dorit TrudleriD· 2 shared Maria V. TalantovaiD· 2 shared Mayra Blanco· 2 shared Melissa Luevanos· 2 shared Michael BulaiD· 2 shared Nicholas J. SchorkiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersNeuroscience

Stuart A. LiptonORCID

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4 papers

Recent·Most cited

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids

Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria V. Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, , Stuart A. Lipton

This study uses human iPSC-derived cortical organoids to model familial Alzheimer's disease and shows that autophagy activators reduce pathological Tau and Aβ accumulation and rescue synaptic loss.

Advanced Science · Jan 27, 2026Peer-reviewedNeuroscience

S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity

Xu Zhang, Roman Vlkolinský, Chongyang Wu, Nima Dolatabadi, Henry R. Scott, Olga Prikhodko, Andrew Zhang, Mayra Blanco, Nhi Lang, Juan Piña-Crespo, Tomohiro Nakamura, Marisa Roberto, Stuart A. Lipton

This study shows that S-nitrosylation of CRTC1 impairs CREB-dependent gene expression in Alzheimer's disease models, leading to synaptic dysfunction and suggesting a therapeutic target.

Proceedings of the National Academy of Sciences · Feb 27, 2025Peer-reviewedNeuroscience

Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

Dorit Trudler, Swagata Ghatak, Michael Bula, James Parker, Maria V. Talantova, Melissa Luevanos, Sergio R. Labra, Titas Grabauskas, Sarah Moore Noveral, Mayu Teranaka, Emily Schahrer, Nima Dolatabadi, Clare Bakker, Kevin M. Lopez, Abdullah Sultan, , Stuart A. Lipton

Autism-like MEF2C+/- patient hiPSC models show miRNA-mediated overproduction of astrocytes and hyperactivity of neurons.

Molecular Psychiatry · Sep 30, 2024Peer-reviewedNeuroscience

Metabolic bypass rescues aberrant S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer's disease human neurons

Alexander Y. Andreyev, Hongmei Yang, Paschalis‐Thomas Doulias, Nima Dolatabadi, Xu Zhang, Melissa Luevanos, Mayra Blanco, Christine Baal, Ivan Putra, Tomohiro Nakamura, Harry Ischiropoulos, Steven R. Tannenbaum, Stuart A. Lipton

This study identifies a metabolic block in the TCA cycle in Alzheimer's disease neurons and shows that dimethyl succinate treatment rescues mitochondrial function and synapse loss.

Advanced Science · Jan 18, 2024Peer-reviewedNeuroscience