NeurosciencebioRxivPreprint
Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease
Atsushi Hori, Tomohiko Ai, Takashi Hato…·Takashi Miida
The paper shows that PSEN1 variants in early-onset Alzheimer's disease cause abnormal Ca2+ bursts in neurons via RyR2, which can be suppressed by carvedilol.
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