Takashi Hato

Shared and Specific miRNA-mRNA in Human and Murine Acute Kidney Injury

The paper compares miRNA-mRNA profiles across human and murine AKI models to identify shared and specific molecular programs associated with different injury etiologies and biological heterogeneity.

Dysregulated flow responses drive pathogenesis in a cellular model of Sturge-Weber syndrome

This study investigates how dysregulated flow responses in endothelial cells contribute to Sturge-Weber syndrome pathogenesis using cellular models and omics analyses.

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

The chromatin landscape of healthy and injured cell types in the human kidney

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editing

This study identifies AZIN1 A-to-I editing as a marker of kidney recovery potential following inflammation.

Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease

The paper shows that PSEN1 variants in early-onset Alzheimer's disease cause abnormal Ca2+ bursts in neurons via RyR2, which can be suppressed by carvedilol.

Alterations in protein translation and carboxylic acid catabolic processes in diabetic kidney disease

The paper identifies altered protein translation and carboxylic acid catabolism in diabetic kidney disease using human and mouse models.

Integration of spatial transcriptomic and single cell sequencing identifies expression patterns underlying immune and epithelial cell cross-talk in acute kidney injury

The paper integrates spatial transcriptomics and single cell sequencing to identify immune and epithelial cell cross-talk patterns in acute kidney injury models.

The orchestrated cellular and molecular responses of the kidney to endotoxin define the sepsis timeline

This study uses single-cell RNA sequencing to define the temporal cellular and molecular changes in the kidney during sepsis, identifying key gene expression shifts and communication failures that mark critical points in the sepsis timeline.