Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease
Atsushi Hori, Tomohiko Ai, Takashi Hato, Haruka Inaba, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, Corina Rosales, Wado Akamatsu, Takashi Murayama, Nagomi Kurebayashi, Takashi Sakurai, Takashi Miida
The paper shows that PSEN1 variants in early-onset Alzheimer's disease cause abnormal Ca2+ bursts in neurons via RyR2, which can be suppressed by carvedilol.
bioRxiv · Sep 15, 2023 · PreprintNeuroscience