Nagomi Kurebayashi

This study defines the mechanism of Ryanozole's Ca2+-dependent modulation of RyR2 using cryo-EM, mutagenesis, and functional assays, revealing its structural basis for CPVT therapy.

Ryanozole, a RyR2-selective stabilizer, prevents stress-induced arrhythmias without impairing cardiac function in CPVT mouse models.

The paper shows that PSEN1 variants in early-onset Alzheimer's disease cause abnormal Ca2+ bursts in neurons via RyR2, which can be suppressed by carvedilol.

This study identifies three RyR2 inhibitors using an ER Ca2+ monitoring assay, showing they suppress arrhythmogenic Ca2+ waves without affecting normal Ca2+ transients.