Author

Jingluan Han

ORCID 0000-0002-9070-2537Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Huan CheniD· 1 shared Huapeng Li· 1 shared Xinping Tan· 1 shared Ye Bu· 1 shared Zhiyong Dai· 1 shared

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2026-2026 · peak 1/yr

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Huan ChenORCID

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Molecular BiologybioRxivPreprintApr 7, 2026

Precision DNA Impurity Reduction Approaches for Ultra-Pure rAAV Manufacturing

Jingluan Han, Huan Chen, Xinping Tan…·Huapeng Li

The paper evaluates DNA impurity reduction strategies in rAAV manufacturing, finding that TelN/TelROL and I-SceI reduce plasmid backbone DNA to 20-40%, CRISPR/Cas9 to 10-20%, and Cre/LoxP eliminates it without affecting vector titers.

DOI 10.64898/2026.04.07.716878

experimental assay

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