Pathogenic mutations of human phosphorylation sites affect protein-protein interactions
Trëndelina Rrustemi, Katrina Meyer, Yvette Roske, Bora Uyar, Altuna Akalin, Koshi Imami, Yasushi Ishihama, Oliver Daumke, Matthias Selbach
The paper investigates how pathogenic mutations at phosphorylation sites affect protein-protein interactions, showing that such mutations disrupt phosphorylation-dependent motifs and alter cellular functions.
Nature Communications · Apr 11, 2024Peer-reviewedSystems Biology