Oliver Daumke

This study identifies structural elements and dynamics of the Mic60-Mic19 subcomplex crucial for MICOS assembly and crista junction formation.

This study uses cryo-electron tomography to reveal the structure of EHD2 filaments on curved membranes, showing how they stabilize caveolar necks and their role in cellular dynamics.

The paper uses integrative structural biology to model the human Mic60-Mic19 subcomplex and validate its role as a diffusion barrier in mitochondrial crista junctions.

This paper structurally characterizes CCDC127 as a mitochondrial intermembrane space protein involved in the mitoskeleton framework.

The paper identifies CCDC127 as a mitochondrial disulfide relay substrate that interacts with MICOS components, revealing its role in OMM topology and mitochondrial membrane organization.

This paper introduces a detergent-free method to reconstitute transmembrane proteins into GUVs with complex curvature, enabling functional studies of membrane proteins in physiologically relevant geometries.

This study identifies mitochondrial adaptations in naked mole-rats that confer hypoxia resistance, linking social behavior to molecular evolution.

The paper identifies a drug-like molecule that inhibits EHD4's liposome-stimulated ATPase activity and provides SAR insights for improved inhibitor design.

The paper investigates how pathogenic mutations at phosphorylation sites affect protein-protein interactions, showing that such mutations disrupt phosphorylation-dependent motifs and alter cellular functions.

This study uses CRISPR to correct a dysferlin mutation in muscle stem cells, rescuing protein function and improving muscle regeneration in a mouse model.