C9orf50 is a Targetable Spliceosome Regulator for Cancer Immunotherapy
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Fangzhou Liu, Lulu Zhang, Ming Xing Li, Tao Hou, Yanhua Qi, Jingyang Wang, Sujuan Zhang, Yu Liu, Jiali Liu, , Lvyun Zhu
This study identifies C9orf50 as a spliceosome regulator that, when targeted, converts immunologically cold tumors to hot ones by enhancing immunogenicity and T cell recruitment.
bioRxiv · Mar 13, 2025 · PreprintCancer Biology