Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture
Michiel Vanhooydonck, Maxim Verlee, Marta Santana Silva, Lore Pottie, Annekatrien Boel, Matthias Van Impe, Hanna De Saffel, Lisa Caboor, Piyanoot Tapaneeyaphan, Anne Bonnin, Patrick Segers, Adelbert De Clercq, Andy Willaert, Delfien Syx, Patrick Yves Sips, Bert Louis Callewaert
This study develops a zebrafish model of thoracic aortic dissection and rupture by knocking out SMAD3 and SMAD6 genes, revealing novel pathways and potential therapeutic targets.
bioRxiv · Feb 12, 2024 · PreprintDevelopmental Biology