This study uses a zebrafish model of Marfan syndrome to identify potential therapies through a high-throughput drug screen and luminescence-based phenotyping.

DOI 10.1186/s40360-026-01271-4

zebrafishimaging

𝕏 PostBluesky

GeneticsJACC Basic to Translational SciencePeer-reviewedApr 22, 2026

Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome

Karo De Rycke, Marina Horvat, Lisa Caboor…·Patrick Yves Sips

This paper creates a zebrafish model of Marfan syndrome by disrupting fibrillin genes, finding that fbn2b-/- zebrafish exhibit cardiovascular phenotypes similar to human disease.

3 citationstop 5%

zebrafishexperimental assay

𝕏 PostBluesky

Developmental BiologybioRxivPreprintFeb 12, 2024

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel Vanhooydonck, Maxim Verlee, Marta Santana Silva…·Bert Louis Callewaert

This study develops a zebrafish model of thoracic aortic dissection and rupture by knocking out SMAD3 and SMAD6 genes, revealing novel pathways and potential therapeutic targets.

1 citation

zebrafishexperimental assay

𝕏 PostBluesky