A 'double-edged' role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
Serena Notartomaso, Nico Antenucci, Mariacristina Mazzitelli, Xavier Rovira, Serena Boccella, Flavia Ricciardi, Francesca Liberatore, Xavier Gómez‐Santacana, Tiziana Imbriglio, Milena Cannella, Charleine Zussy, Livio Luongo, Sabatino Maione, Cyril Goudet, Giuseppe Battaglia, , Volker Neugebauer
The paper uses light-sensitive drugs to show that mGlu5 receptor blockade in specific brain regions has different effects on pain, with some areas reducing analgesia and others enhancing it.
eLife · Jul 22, 2024Peer-reviewedNeuroscience