Xavier Rovira

Time-resolved structures of β2-adrenergic receptor modulation by a photoswitchable beta-blocker

This study captures time-resolved structures of β2AR modulated by a photoswitchable beta-blocker, revealing conformational changes linked to ligand isomerization and receptor function.

A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light

This paper develops a photoswitchable positive allosteric modulator of mGlu5 that activates the receptor in response to light, demonstrating reversible isomerization and light-dependent activity.

A 'double-edged' role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

The paper uses light-sensitive drugs to show that mGlu5 receptor blockade in specific brain regions has different effects on pain, with some areas reducing analgesia and others enhancing it.

Photocontrol of endogenous glycine receptors in vivo

This study introduces Glyght, a light-controlled GlyR ligand that selectively modulates glycinergic neurotransmission in vivo, offering new tools for studying inhibitory circuits and phototherapies.