Cyril Goudet

Tilted striatofugal balance and beneficial effects of facilitating mGlu4 receptor activity in the Fmr1-/- mouse model of Fragile X Syndrome

The paper investigates D1/D2-SPN balance in FXS mice and shows that mGlu4 facilitation rescues social deficits.

Shedding light on left hippocampal mGlu5 in Alzheimer's disease

The paper shows that mGlu5 expression is asymmetrically distributed in the hippocampus of wild-type mice, and this asymmetry is lost in AD model mice, with left-specific inhibition of mGlu5 restoring memory and reversing pathology.

A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light

This paper develops a photoswitchable positive allosteric modulator of mGlu5 that activates the receptor in response to light, demonstrating reversible isomerization and light-dependent activity.

A 'double-edged' role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

The paper uses light-sensitive drugs to show that mGlu5 receptor blockade in specific brain regions has different effects on pain, with some areas reducing analgesia and others enhancing it.

Differential reduction of neuropathic pain symptoms by mGlu4-mediated neuromodulation of amygdala circuits

This study shows that activating mGlu4 receptors in the amygdala reduces neuropathic pain symptoms in mice, with differential effects based on the side of activation.