Single-cell trajectories in metastatic urothelial carcinoma reveal tumor-immune reprogramming and macrophage-driven resistance to PD-(L)1 blockade
Ronan Flippot, Amélie Roehrig, Julien Vibert, Nicolas Stransky, Luc Cabel, Kevin Mulder, Benjamin Besse, Claudio Nicotra, Maud Ngo Camus, Christophe Massard, Étienne Rouleau, Gérôme Jules-Clément, Alicia Tran-Dien, Lambros Tselikas, Constance Thibault, , Yohann Loriot
This study uses single-cell RNA sequencing to analyze metastatic urothelial carcinoma and identifies macrophage-driven resistance to PD-(L)1 blockade as a key mechanism.
bioRxiv · Apr 2, 2026 · PreprintCancer Biology