Cancer BiologybioRxivPreprint
Single-cell trajectories in metastatic urothelial carcinoma reveal tumor-immune reprogramming and macrophage-driven resistance to PD-(L)1 blockade
Ronan Flippot, Amélie Roehrig, Julien Vibert…·Yohann Loriot
This study uses single-cell RNA sequencing to analyze metastatic urothelial carcinoma and identifies macrophage-driven resistance to PD-(L)1 blockade as a key mechanism.