PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification
José Antonio Valer, Alexandre Deber, Marius Wits, Carolina Pimenta-Lopes, Marie‐José Goumans, José Luís Rosa, Gonzalo Sánchez‐Duffhues, Francesc Ventura
This study confirms that PI3K inhibition with BYL719 prevents heterotopic ossification by blocking osteochondroprogenitor specification and reducing inflammation.
eLife · Jun 17, 2025Peer-reviewedMolecular Biology