Francesc Ventura

HERC1 Loss of Function Causes a Developmental Disorder with Impaired Hippocampal Function

This study shows that HERC1 loss causes neurodevelopmental abnormalities in mice, including hippocampal dysfunction and sex-dependent synaptic defects.

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

This study confirms that PI3K inhibition with BYL719 prevents heterotopic ossification by blocking osteochondroprogenitor specification and reducing inflammation.

Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva

The paper uses multi-omics analyses to identify signaling dysregulation in FOP, highlighting AP-1 as a novel therapeutic target.