Author

Joshua I. Siner

Washington University in St. LouisORCID 0000-0002-9103-3224Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Abigail AjaneliD· 1 shared Christopher Letson· 1 shared Craig N. MorrelliD· 1 shared Ei Thanda TuniD· 1 shared Jorge Di PaolaiD· 1 shared Kimsey PlatteniD· 1 shared Lilian AntunesiD· 1 shared Mary C. Fulbright· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Abigail AjanelORCID

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1 paper

Recent·Most cited

TNFα drives platelet hyperreactivity and thromboinflammation through regulation of hematopoietic stem and progenitor cells.

Joshua I. Siner, Molly Brakhane, Kimsey Platten, Abigail Ajanel, Ei Thanda Tun, Lilian Antunes, Thomas Girard, Nina M. Lasky, Mary C. Fulbright, Christopher Letson, Yoon-A Kang, Craig N. Morrell, Stephen T. Oh, Jorge Di Paola

This study shows TNFα increases platelet reactivity and thromboinflammation by expanding and reprogramming hematopoietic stem and progenitor cells, not directly affecting megakaryocytes.

bioRxiv · Sep 29, 2026 · PreprintCell Biology