Stephen T. Oh

TNFα drives platelet hyperreactivity and thromboinflammation through regulation of hematopoietic stem and progenitor cells.

This study shows TNFα increases platelet reactivity and thromboinflammation by expanding and reprogramming hematopoietic stem and progenitor cells, not directly affecting megakaryocytes.

Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation

This study shows UPR signaling promotes myeloid cell production and collaborates with Jak2V617F mutation to exacerbate disease in polycythemia vera.

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

The paper characterizes immune microenvironment dysregulation in multiple myeloma using single-cell data and links it to disease progression and patient outcomes.

JAK2V617F Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones

This study shows that leukemic clones can evolve independently of JAK2V617F in MPNs and contribute to disease progression through pro-inflammatory environments.

Interpretable spatial cell learning enhances the characterization of patient tissue microenvironments with highly multiplexed imaging data

InterSTELLAR improves microenvironment characterization in cancer using multiplexed imaging data by linking tissue subtypes to clinically relevant cell communities.

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

IMC-Denoise improves Imaging Mass Cytometry image quality by reducing noise and artifacts, enhancing downstream analysis.

Microglial Heterogeneity in a Mouse Model of Alzheimer’s Disease: A Mass Cytometry Analysis

The paper uses mass cytometry to analyze microglial heterogeneity in a mouse Alzheimer’s model, identifying distinct clusters that vary with age and disease state.