Author

Abigail Ajanel

Washington University in St. LouisORCID 0000-0002-4601-3769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Jorge Di PaolaiD· 2 shared Nina M. Lasky· 2 shared Adam BalutowskiiD· 1 shared Alice LiuiD· 1 shared Ashutosh KumariD· 1 shared Chloe Grace MeyeriD· 1 shared Christopher Letson· 1 shared Craig N. MorrelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Jorge Di PaolaORCID

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2 papers

Recent·Most cited

TNFα drives platelet hyperreactivity and thromboinflammation through regulation of hematopoietic stem and progenitor cells.

Joshua I. Siner, Molly Brakhane, Kimsey Platten, Abigail Ajanel, Ei Thanda Tun, Lilian Antunes, Thomas Girard, Nina M. Lasky, Mary C. Fulbright, Christopher Letson, Yoon-A Kang, Craig N. Morrell, Stephen T. Oh, Jorge Di Paola

This study shows TNFα increases platelet reactivity and thromboinflammation by expanding and reprogramming hematopoietic stem and progenitor cells, not directly affecting megakaryocytes.

bioRxiv · Sep 29, 2026 · PreprintCell Biology

LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis

John D. Tranter, Ryan T. Mikami, Ashutosh Kumar, Gavriel Brown, Tarek Mohamed Abd El‐Aziz, Yonghui Zhao, Prakash Arullampalam, Katrina J. Ashworth, Vishwanath Jha, Nihil Abraham, Chloe Grace Meyer, Abigail Ajanel, Litao Xie, Yongmei Feng, Juan Hong, , Rajan Sah

This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.

Blood · Jun 20, 2025Peer-reviewedCell Biology