Jorge Di Paola

This study shows TNFα increases platelet reactivity and thromboinflammation by expanding and reprogramming hematopoietic stem and progenitor cells, not directly affecting megakaryocytes.

This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.

This study uses isotopically nonstationary 13C metabolic flux analysis to measure carbon fluxes in resting and thrombin-activated human platelets, revealing metabolic shifts during activation.

The paper develops a method to recover and analyze targeted transcriptome subsets from scRNA-seq libraries, improving sequencing depth and gene detection.