Jessica L. MacDonald

This study identifies Mecp2-null astrocytes as drivers of precocious perineuronal net formation in RTT by inducing Hapln1 expression and accelerating PNN maturation.

This study shows that vitamin D modulates gene expression and behavioral traits in Mecp2 heterozygous Rett syndrome mice, suggesting it could be a therapeutic option.

This paper shows miR-409-3p represses Cited2 to regulate the fate of callosal and corticospinal projection neurons during development.

This study shows that Cited2 conditional knockout in the forebrain leads to neocortical abnormalities and specific behavioral deficits resembling neurodevelopmental disorders.

The paper identifies a microRNA cluster unique to placental mammals that promotes corticospinal neuron identity by repressing LMO4, a callosal gene, thereby contributing to neuronal subtype diversity in the mammalian brain.