Jeffrey D. Macklis

The paper identifies how Lrrtm2 sequestration in growth cones disrupts axon guidance, leading to abnormal amygdala innervation in callosal projection neurons, linking Bcl11a deletion to ASD/ID mechanisms.

This study generates corticospinal-like neurons from SOX6+/NG2+ cortical progenitors using a multi-component transcriptional construct, achieving high fidelity in morphology, molecular, transcriptomic, and electrophysiological characteristics.

The paper identifies context-specific subcellular RNA regulation in growth cones of developing cortical neurons and links it to neurodevelopmental disorders.

The paper investigates mRNA dynamics and axonal transport in cerebral cortex projection neurons in vivo, identifying cis-regulatory elements and transport mechanisms for specific mRNA classes.

The paper identifies subtype-specific ribosomal complex protein compositions in cortical projection neurons during axonal connectivity formation.

This study identifies Bcl11b's role in regulating subcerebral projection neuron axon development through both cell-autonomous and non-cell-autonomous mechanisms involving Cdh13.

BEAM generates two genetically distinct cell populations for mosaic analysis by using sparse recombinase activation to label cells with green or red fluorescent protein.

The paper identifies topographic principles in the corpus callosum that guide axon connectivity between brain hemispheres through symmetric adhesion molecule levels and co-fasciculation.

The paper tests fluorescent timer proteins to synchronize cortical progenitor cell differentiation from hPSCs but finds they fail to achieve synchronized fluorescence kinetics.

This study identifies Cbln1 as a molecular regulator directing thoraco-lumbar axon extension by corticospinal neurons, showing its sufficiency but not necessity for this targeting.

This study shows that the ASD/ID gene Bcl11a is essential for precise axonal targeting and circuit formation in CPN, with its deletion causing behavioral and molecular disruptions in mice.

This study identifies Tle4's role in both the acquisition and maintenance of corticothalamic projection neuron identity through epigenetic regulation of Fezf2 expression.

The paper develops nanoRibo-seq, an ultra-low-input method for Ribo-seq, revealing uORF translation in specific neurons.

The paper shows that inhibiting SIRT1 with modRNA-enhanced Fezf2 expression improves SCPN/corticospinal neuron differentiation from mES cells.

The paper identifies Lumican as a factor regulating axon collateralization in cervical corticospinal neurons through inter-neuronal crosstalk.

The paper identifies a microRNA cluster unique to placental mammals that promotes corticospinal neuron identity by repressing LMO4, a callosal gene, thereby contributing to neuronal subtype diversity in the mammalian brain.